Global Gene Synthesis (Research Use) Market to Reach US$4.5 Billion by 2030

The global market for Gene Synthesis (Research Use) estimated at US$2.1 Billion in the year 2024, is expected to reach US$4.5 Billion by 2030, growing at a CAGR of 14.0% over the analysis period 2024-2030. Solid-Phase Synthesis, one of the segments analyzed in the report, is expected to record a 12.9% CAGR and reach US$2.4 Billion by the end of the analysis period. Growth in the Chip-based Synthesis segment is estimated at 15.1% CAGR over the analysis period.

The U.S. Market is Estimated at US$559.3 Million While China is Forecast to Grow at 18.5% CAGR

The Gene Synthesis (Research Use) market in the U.S. is estimated at US$559.3 Million in the year 2024. China, the world`s second largest economy, is forecast to reach a projected market size of US$953.4 Million by the year 2030 trailing a CAGR of 18.5% over the analysis period 2024-2030. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at a CAGR of 10.4% and 12.4% respectively over the analysis period. Within Europe, Germany is forecast to grow at approximately 11.1% CAGR.

Global Gene Synthesis (Research Use) Market – Key Trends & Drivers Summarized

Why Is Gene Synthesis Transforming Research in Genetic Engineering?

Gene synthesis has become an indispensable tool in modern molecular biology, enabling researchers to create custom DNA sequences with high precision and efficiency. Unlike traditional cloning techniques that rely on existing genetic material, gene synthesis allows scientists to design and construct novel genes from scratch, facilitating breakthroughs in synthetic biology, genetic engineering, and biomedical research. This capability has revolutionized studies in gene function, protein engineering, and drug discovery, making gene synthesis a critical resource for research institutions, pharmaceutical companies, and biotech firms.

Advancements in DNA assembly technologies, such as enzymatic synthesis and chip-based DNA printing, have significantly reduced synthesis costs while increasing speed and accuracy. Automated gene synthesis platforms now allow for the rapid generation of long and complex DNA sequences, enabling large-scale genomic studies and high-throughput screening. The increasing adoption of gene synthesis in CRISPR research, vaccine development, and metabolic pathway engineering has further accelerated its demand. As scientists continue to explore new frontiers in genomics and personalized medicine, gene synthesis is poised to play a crucial role in unlocking the full potential of synthetic biology.

Which Research Fields Are Driving the Demand for Gene Synthesis?

Gene synthesis is widely utilized across multiple scientific disciplines, each benefiting from its ability to precisely manipulate genetic sequences. In synthetic biology, researchers use gene synthesis to design and optimize biological systems, enabling the production of biofuels, specialty chemicals, and engineered microbes for industrial applications. The pharmaceutical industry relies on synthesized genes for antibody development, protein expression studies, and vaccine production, particularly in mRNA-based vaccine research.

Agricultural biotechnology is another major sector leveraging gene synthesis for crop improvement and pest resistance studies. Scientists are engineering plant genomes to enhance drought tolerance, nutrient content, and yield performance, providing sustainable solutions to global food security challenges. Additionally, gene synthesis plays a vital role in virology and epidemiology, where researchers construct viral genomes to study pathogen evolution and develop targeted antiviral therapies. The growing demand for precision genetics in these fields continues to fuel the expansion of the gene synthesis market, making it an essential tool for cutting-edge scientific research.

What Are the Latest Technological Advancements in Gene Synthesis?

Technological advancements in gene synthesis have significantly improved the accuracy, efficiency, and scalability of DNA synthesis processes. One of the most groundbreaking innovations is enzymatic DNA synthesis, which eliminates the need for traditional phosphoramidite chemistry, reducing chemical waste and increasing synthesis speed. This approach has enabled the development of cost-effective and environmentally friendly gene synthesis methods, making DNA fabrication more accessible to researchers worldwide.

Additionally, the integration of artificial intelligence (AI) and machine learning in gene design and optimization has enhanced sequence assembly, reducing error rates and improving functional gene expression. AI-driven algorithms can predict secondary structures, codon biases, and regulatory elements, ensuring optimal gene performance in experimental systems. The use of microfluidic platforms and high-throughput DNA synthesis techniques has also accelerated the production of large DNA libraries for applications such as protein engineering and directed evolution. These technological advancements are revolutionizing gene synthesis, enabling scientists to push the boundaries of genetic research with unprecedented precision.

What Factors Are Fueling the Growth of the Gene Synthesis Market?

The growth in the gene synthesis market is driven by several factors, including increasing demand for synthetic biology applications, advancements in DNA synthesis technology, and expanding research in genetic engineering. The pharmaceutical and biotechnology sectors are investing heavily in synthetic gene constructs for drug discovery, antibody engineering, and vaccine development, contributing to market expansion. Additionally, government funding for genomics research and synthetic biology initiatives has further propelled demand for gene synthesis services.

The growing need for customized genetic constructs in agricultural biotechnology, industrial microbiology, and metabolic engineering has also boosted market adoption. The rise of cloud-based bioinformatics platforms and AI-driven gene design tools has made gene synthesis more efficient and cost-effective, allowing researchers to accelerate discovery and innovation. Furthermore, the increasing use of gene synthesis in personalized medicine and gene therapy research is expected to drive long-term market growth. As the field of synthetic biology continues to evolve, gene synthesis will remain a fundamental technology shaping the future of genetic research and biotechnological advancements.